A necessity for MAP kinase activation in mammalian spatial learning.

  title={A necessity for MAP kinase activation in mammalian spatial learning.},
  author={Joel C. Selcher and Coleen M Atkins and James M. Trzaskos and Richard E Paylor and J David Sweatt},
  journal={Learning & memory},
  volume={6 5},
Although the biochemical mechanisms underlying learning and memory have not yet been fully elucidated, mounting evidence suggests that activation of protein kinases and phosphorylation of their downstream effectors plays a major role. Recent findings in our laboratory have shown a requirement for the mitogen-activated protein kinase (MAPK) cascade in hippocampal synaptic plasticity. Therefore, we used an inhibitor of MAPK activation, SL327, to test the role of the MAPK cascade in hippocampus… CONTINUE READING
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