A naturally occurring insertion of a single amino acid rewires transcriptional regulation by glucocorticoid receptor isoforms.

@article{ThomasChollier2013ANO,
  title={A naturally occurring insertion of a single amino acid rewires transcriptional regulation by glucocorticoid receptor isoforms.},
  author={Morgane Thomas-Chollier and Lisa C. Watson and Samantha B. Cooper and Miles A Pufall and Jennifer S E Liu and Katja Borzym and Martin Vingron and Keith R. Yamamoto and Sebastiaan H Meijsing},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2013},
  volume={110 44},
  pages={17826-31}
}
In addition to guiding proteins to defined genomic loci, DNA can act as an allosteric ligand that influences protein structure and activity. Here we compared genome-wide binding, transcriptional regulation, and, using NMR, the conformation of two glucocorticoid receptor (GR) isoforms that differ by a single amino acid insertion in the lever arm, a domain that adopts DNA sequence-specific conformations. We show that these isoforms differentially regulate gene expression levels through two… CONTINUE READING

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