A naturally occurring calcineurin variant inhibits FoxO activity and enhances skeletal muscle regeneration

@article{LaraPezzi2007ANO,
  title={A naturally occurring calcineurin variant inhibits FoxO activity and enhances skeletal muscle regeneration},
  author={Enrique Lara-Pezzi and Nadine Winn and Angelika Paul and Karl J. A. McCullagh and Esfir Slominsky and Maria Paola Santini and Foteini Mourkioti and Padmini Sarathchandra and Satsuki Fukushima and Ken Suzuki and Nadia Rosenthal},
  journal={The Journal of Cell Biology},
  year={2007},
  volume={179},
  pages={1205 - 1218}
}
The calcium-activated phosphatase calcineurin (Cn) transduces physiological signals through intracellular pathways to influence the expression of specific genes. Here, we characterize a naturally occurring splicing variant of the CnAbeta catalytic subunit (CnAbeta1) in which the autoinhibitory domain that controls enzyme activation is replaced with a unique C-terminal region. The CnAbeta1 enzyme is constitutively active and dephosphorylates its NFAT target in a cyclosporine-resistant manner… CONTINUE READING