A naturally derived outer-membrane vesicle vaccine protects against lethal pulmonary Burkholderia pseudomallei infection.

@article{Nieves2011AND,
  title={A naturally derived outer-membrane vesicle vaccine protects against lethal pulmonary Burkholderia pseudomallei infection.},
  author={Wildaliz Nieves and Saja K Asakrah and Omar Qazi and Katherine A. Brown and Jonathan R. Kurtz and David P AuCoin and James B. McLachlan and Chad J Roy and Lisa A Morici},
  journal={Vaccine},
  year={2011},
  volume={29 46},
  pages={8381-9}
}
Burkholderia pseudomallei, and other members of the Burkholderia, are among the most antibiotic-resistant bacterial species encountered in human infection. Mortality rates associated with severe B. pseudomallei infection approach 50% despite therapeutic treatment. A protective vaccine against B. pseudomallei would dramatically reduce morbidity and mortality in endemic areas and provide a safeguard for the U.S. and other countries against biological attack with this organism. In this study, we… CONTINUE READING

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