A natural product-like inhibitor of NEDD8-activating enzyme.

Abstract

The natural product-like 6,6″-biapigenin has been identified as only the second inhibitor of NEDD8-activating enzyme using virtual screening. This compound was active in enzyme and cell-based assays, with potency in the micromolar range. 
DOI: 10.1039/c0cc04927a

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Cite this paper

@article{Leung2011ANP, title={A natural product-like inhibitor of NEDD8-activating enzyme.}, author={Chung-Hang Leung and Daniel Shiu-Hin Chan and Hui Yang and Ruben Abagyan and Simon Ming-yuen Lee and Guo-yuan Zhu and Wang-fun Fong and Dik-Lung Ma}, journal={Chemical communications}, year={2011}, volume={47 9}, pages={2511-3} }