A natural history of FUT2 polymorphism in humans.

  title={A natural history of FUT2 polymorphism in humans.},
  author={Anna Ferrer-Admetlla and Martin Sikora and Hafid Laayouni and A Franco Esteve and Francis Roubinet and Antoine Blancher and Francesc Calafell and Jaume Bertranpetit and Ferran Casals},
  journal={Molecular biology and evolution},
  volume={26 9},
Because pathogens are powerful selective agents, host-cell surface molecules used by pathogens as identification signals can reveal the signature of selection. Most of them are oligosaccharides, synthesized by glycosyltransferases. One known example is balancing selection shaping ABO evolution as a consequence of both, A and B antigens being recognized as receptors by some pathogens, and anti-A and/or anti-B natural antibodies produced by hosts conferring protection against the numerous… CONTINUE READING


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