A natural disruption of the secretory group II phospholipase A2 gene in inbred mouse strains.

@article{Kennedy1995AND,
  title={A natural disruption of the secretory group II phospholipase A2 gene in inbred mouse strains.},
  author={Brian P. Kennedy and Paul Payette and John Mudgett and Peter Vadas and Waldemar Pruzanski and Millie Kwan and Chun Meng Tang and D. E. Rancourt and Wanda A Cromlish},
  journal={The Journal of biological chemistry},
  year={1995},
  volume={270 38},
  pages={22378-85}
}
The synovial fluid or group II secretory phospholipase A2 (sPLA2) has been implicated as an important agent involved in a number of inflammatory processes. In an attempt to determine the role of sPLA2 in inflammation, we set out to generate sPLA2-deficient mice. During this investigation, we observed that in a number of inbred mouse strains, the sPLA2 gene was already disrupted by a frameshift mutation in exon 3. This mutation, a T insertion at position 166 from the ATG of the cDNA, terminates… CONTINUE READING