A natural antisense transcript regulates Zeb2/Sip1 gene expression during Snail1-induced epithelial-mesenchymal transition.

@article{Beltrn2008ANA,
  title={A natural antisense transcript regulates Zeb2/Sip1 gene expression during Snail1-induced epithelial-mesenchymal transition.},
  author={Manuel Domingo Beltr{\'a}n and Isabel Puig and Cristina Garc{\'i}a de la Pe{\~n}a and Jos{\'e} Miguel Garc{\'i}a and Ana Bel{\'e}n Alvarez and Raul Pena and F{\'e}lix Bonilla and Antonio Garc{\'i}a de Herreros},
  journal={Genes & development},
  year={2008},
  volume={22 6},
  pages={756-69}
}
Expression of Snail1 in epithelial cells triggers an epithelial-mesenchymal transition (EMT). Here, we demonstrate that the synthesis of Zeb2, a transcriptional repressor of E-cadherin, is up-regulated after Snail1-induced EMT. Snail1 does not affect the synthesis of Zeb2 mRNA, but prevents the processing of a large intron located in its 5'-untranslated region (UTR). This intron contains an internal ribosome entry site (IRES) necessary for the expression of Zeb2. Maintenance of 5'-UTR Zeb2… CONTINUE READING
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