A natural IgA-anti-F(ab')2gamma autoantibody occurring in healthy individuals and kidney graft recipients recognizes an IgG1 hinge region epitope.

@article{Terness1996ANI,
  title={A natural IgA-anti-F(ab')2gamma autoantibody occurring in healthy individuals and kidney graft recipients recognizes an IgG1 hinge region epitope.},
  author={Peter I Terness and Dan Navolan and Louis Moroder and Frank Siedler and Elisabeth Weyher and Ingrid Kohl and Ch. Dufter and Martin Welschof and Doina Drugărin and Frank Schneider and Gerhard Opelz},
  journal={Journal of immunology},
  year={1996},
  volume={157 9},
  pages={4251-7}
}
Natural anti-IgG autoantibodies are found both in healthy individuals and in patients with certain diseases. One group of these Abs recognizes epitopes located in the F(ab')2 region of the IgG molecule. The immunoregulatory role of these Abs in healthy individuals, graft rejection, and disease was previously studied, usually with a focus on the characterization of anti-idiotypic Abs. In the present study, we characterize the epitope recognized by an anti-F(ab')2gamma autoantibody of the IgA… CONTINUE READING