A native-like SOSIP.664 trimer based on an HIV-1 subtype B env gene.

@article{Pugach2015ANS,
  title={A native-like SOSIP.664 trimer based on an HIV-1 subtype B env gene.},
  author={Pavel Pugach and Gabriel Ozorowski and Albert Cupo and Rajesh P. Ringe and Anila Yasmeen and Natalia de Val and Ronald Derking and Helen J Kim and Jacob Korzun and Michael Golabek and Kevin de los Reyes and Thomas J. Ketas and Jean-Philippe Julien and Dennis R. Burton and Ian A. Wilson and Rogier W. Sanders and Per Johan Klasse and Andrew B. Ward and John P. Moore},
  journal={Journal of virology},
  year={2015},
  volume={89 6},
  pages={3380-95}
}
UNLABELLED Recombinant trimeric mimics of the human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein (Env) spike should expose as many epitopes as possible for broadly neutralizing antibodies (bNAbs) but few, if any, for nonneutralizing antibodies (non-NAbs). Soluble, cleaved SOSIP.664 gp140 trimers based on the subtype A strain BG505 approach this ideal and are therefore plausible vaccine candidates. Here, we report on the production and in vitro properties of a new SOSIP.664 trimer… CONTINUE READING
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