A nanobody targeting the F-actin capping protein CapG restrains breast cancer metastasis

Abstract

Aberrant turnover of the actin cytoskeleton is intimately associated with cancer cell migration and invasion. Frequently however, evidence is circumstantial, and a reliable assessment of the therapeutic significance of a gene product is offset by lack of inhibitors that target biologic properties of a protein, as most conventional drugs do, instead of the… (More)
DOI: 10.1186/bcr3585

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