A nanobody directed to a functional epitope on VEGF, as a novel strategy for cancer treatment.

@article{Farajpour2014AND,
  title={A nanobody directed to a functional epitope on VEGF, as a novel strategy for cancer treatment.},
  author={Zahra Farajpour and Fatemeh Rahbarizadeh and Bahram Kazemi and Davoud Ahmadvand},
  journal={Biochemical and biophysical research communications},
  year={2014},
  volume={446 1},
  pages={132-6}
}
Compelling evidence suggests that vascular endothelial growth factor (VEGF), due to its essential role in angiogenesis, is a critical target for cancer treatment. Neutralizing monoclonal antibodies against VEGF are important class of drugs used in cancer therapy. However, the cost of production, large size, and immunogenicity are main drawbacks of conventional monoclonal therapy. Nanobodies are the smallest antigen-binding antibody fragments, which occur naturally in camelidae. Because of their… CONTINUE READING

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