A myosin phosphatase targeting subunit isoform transition defines a smooth muscle developmental phenotypic switch.

@article{Dirksen2000AMP,
  title={A myosin phosphatase targeting subunit isoform transition defines a smooth muscle developmental phenotypic switch.},
  author={Wessel P. Dirksen and Franjo Vladic and Steven Fisher},
  journal={American journal of physiology. Cell physiology},
  year={2000},
  volume={278 3},
  pages={C589-600}
}
Smooth muscle myosin phosphatase dephosphorylates the regulatory myosin light chain and thus mediates smooth muscle relaxation. The activity of this myosin phosphatase is dependent upon its myosin-targeting subunit (MYPT1). Isoforms of MYPT1 have been identified, but how they are generated and their relationship to smooth muscle phenotypes is not clear. Cloning of the middle section of chicken and rat MYPT1 genes revealed that each gene gave rise to isoforms by cassette-type alternative… CONTINUE READING

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