A mutator phenotype in cancer.

  title={A mutator phenotype in cancer.},
  author={L. A. Loeb},
  journal={Cancer research},
  volume={61 8},
We have proposed that an early step in tumor progression is the expression of a mutator phenotype resulting from mutations in genes that normally function in the maintenance of genetic stability. There is new and strong experimental evidence that supports the concept of a mutator phenotype in cancer. As technologies for chromosomal visualization and DNA advance, there are increasing data that human cancer cells contain large numbers of mutations. First, I will review the concept of a mutator… CONTINUE READING
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