A mutational model of carcinogenesis.

@article{Morris1991AMM,
  title={A mutational model of carcinogenesis.},
  author={James A. Morris},
  journal={Anticancer research},
  year={1991},
  volume={11 5},
  pages={1731-4}
}
A model of carcinogenesis based on spontaneous somatic mutation in expanding cell clones is presented and compared with previous mathematical treatments of this concept. The model shows that if cancer is purely a consequence of gene mutation then four independent mutations are required. To explain the marked increase in the incidence of cancer with age it… CONTINUE READING