A mutational analysis of the transforming functions of the E8 protein of bovine papillomavirus type 4.

@article{OBrien1999AMA,
  title={A mutational analysis of the transforming functions of the E8 protein of bovine papillomavirus type 4.},
  author={Vincent Edward O'Brien and Gholam Hossein Ashrafi and G. Joan Grindlay and Rosalie A Anderson and Maria Saveria Campo},
  journal={Virology},
  year={1999},
  volume={255 2},
  pages={
          385-94
        }
}
The E8 protein of BPV-4 contributes to transformation of primary bovine cells (PalFs) by inducing anchorage-independent growth and by down-regulating gap junction intercellular communication, likely due to its binding to 16K ductin. We show here that, in addition, E8 confers on PalF cells the ability to grow in low serum and to escape from contact inhibition (focus formation). E8 also transactivates an exogenous human cyclin A gene promoter, suggesting that overexpression of cyclin A is… CONTINUE READING
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