• DOI:10.1038/32911
Corpus ID: 4400661

A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction

@article{Clment1998AMI,
  title={A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction},
  author={Karine Cl{\'e}ment and C. Vaisse and N. Lahlou and S. Cabrol and V. Pelloux and D. Cassuto and M. Gourmelen and C. Dina and J. Chambaz and Jean-Marc Lacorte and A. Basdevant and P. Bougn{\`e}res and Y. Lebouc and P. Froguel and B. Guy-grand},
  journal={Nature},
  year={1998},
  volume={392},
  pages={398-401}
}

Karine Clément, C. Vaisse, +12 authors B. Guy-grand

Published 1998

Biology, Medicine

Nature

The adipocyte-specific hormone leptin, the product of the obese (ob) gene,regulates adipose-tissue mass through hypothalamic effects on satiety and energy expenditure. Leptin acts through the leptin receptor, a single-transmembrane-domain receptor of the cytokine-receptor family. In rodents, homozygous mutations ingenes encoding leptin or the leptin receptor cause early-onsetmorbid obesity, hyperphagia and reduced energy expenditure. These rodents also show hypercortisolaemia, alterations in… CONTINUE READING

View on Nature

ncbi.nlm.nih.gov

Save to Library

Create Alert

Cite

Launch Research Feed