A mutation in the envelope protein fusion loop attenuates mouse neuroinvasiveness of the NY99 strain of West Nile virus.

@article{Zhang2006AMI,
  title={A mutation in the envelope protein fusion loop attenuates mouse neuroinvasiveness of the NY99 strain of West Nile virus.},
  author={Shuliu Zhang and Li Li and Sara E Woodson and Claire Y-H Huang and Richard M. Kinney and Alan D. T. Barrett and David Beasley},
  journal={Virology},
  year={2006},
  volume={353 1},
  pages={
          35-40
        }
}
Substitutions were engineered individually and in combinations at the fusion loop, receptor-binding domain and a stem-helix structure of the envelope protein of a West Nile virus strain, NY99, and their effects on mouse virulence and presentation of epitopes recognized by monoclonal antibodies (MAbs) were assessed. A single substitution within the fusion loop (L107F) attenuated mouse neuroinvasiveness of NY99. No substitutions attenuated NY99 neurovirulence. The L107F mutation also abolished… CONTINUE READING

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