A mutation in the age-1 gene in Caenorhabditis elegans lengthens life and reduces hermaphrodite fertility.

@article{Friedman1988AMI,
  title={A mutation in the age-1 gene in Caenorhabditis elegans lengthens life and reduces hermaphrodite fertility.},
  author={Dr. Richard B. Friedman and Thomas Johnson},
  journal={Genetics},
  year={1988},
  volume={118 1},
  pages={75-86}
}
age-1(hx546) is a recessive mutant allele in Caenorhabditis elegans that results in an increase in mean life span averaging 40% and in maximal life span averaging 60% at 20 degrees; at 25 degrees age-1(hx546) averages a 65% increase in mean life span (25.3 days vs. 15.0 days) and a 110% increase in maximum life span (46.2 days vs. 22.0 days for wild-type hermaphrodites). Mutant males also show extended life spans. age-1(hx546) is associated with a 75% decrease in hermaphrodite self-fertility as… CONTINUE READING
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