A mutation in the RCC1-related protein pim1 results in nuclear envelope fragmentation in fission yeast.

@article{Demeter1995AMI,
  title={A mutation in the RCC1-related protein pim1 results in nuclear envelope fragmentation in fission yeast.},
  author={Judit Demeter and Mary Morphew and Shelley Sazer},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1995},
  volume={92 5},
  pages={1436-40}
}
Members of the RCC1 protein family are chromatin-associated guanine nucleotide exchange factors that have been implicated in diverse cellular processes in various organisms, yet no consensus has been reached as to their primary biological role. The fission yeast Schizosaccharomyces pombe, a single-celled eukaryote, provides an in vivo system in which to study the RCC1/Ran switch by using a temperature-sensitive mutant in the RCC1-related protein pim1. Mitotic entry in the pim1-d1ts mutant is… CONTINUE READING
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