A mutation in the MSH5 gene results in alkylation tolerance.

  title={A mutation in the MSH5 gene results in alkylation tolerance.},
  author={Sonya Bawa and Wei Xiao},
  journal={Cancer research},
  volume={57 13},
DNA methylating agents such as N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) are potent carcinogens; their carcinogenic effect is mainly due to the effect of production of O6-methylguanine (O6 MeG) on DNA. O6 MeG is not only mutagenic but also toxic to the cell because Mer-/Mex- cells unable to remove O6 MeG are very sensitive to killing by MNNG. It has been proposed that repeated futile mismatch correction of O6 MeG-containing bp is responsible for the genotoxicity of the O6 MeG lesion and that… CONTINUE READING
Highly Cited
This paper has 72 citations. REVIEW CITATIONS


Publications citing this paper.
Showing 1-10 of 14 extracted citations

Cumulative effect of multiple loci on genetic susceptibility to familial lung cancer.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology • 2010
View 1 Excerpt

73 Citations

Citations per Year
Semantic Scholar estimates that this publication has 73 citations based on the available data.

See our FAQ for additional information.

Similar Papers

Loading similar papers…