A mutation in the Gsk3-binding domain of zebrafish Masterblind/Axin1 leads to a fate transformation of telencephalon and eyes to diencephalon.

@article{Heisenberg2001AMI,
  title={A mutation in the Gsk3-binding domain of zebrafish Masterblind/Axin1 leads to a fate transformation of telencephalon and eyes to diencephalon.},
  author={Carl-Philipp Heisenberg and Corinne Houart and Masaya Take-uchi and G J Rauch and Neville J. De Young and Pedro Coutinho and Ichiro Masai and Luca Caneparo and Miguel L. Concha and Robert Geisler and Trevor C Dale and Steve W. Wilson and Derek L. Stemple},
  journal={Genes & development},
  year={2001},
  volume={15 11},
  pages={1427-34}
}
Zebrafish embryos homozygous for the masterblind (mbl) mutation exhibit a striking phenotype in which the eyes and telencephalon are reduced or absent and diencephalic fates expand to the front of the brain. Here we show that mbl(-/-) embryos carry an amino-acid change at a conserved site in the Wnt pathway scaffolding protein, Axin1. The amino-acid substitution present in the mbl allele abolishes the binding of Axin to Gsk3 and affects Tcf-dependent transcription. Therefore, Gsk3 activity may… CONTINUE READING
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