A mutation in reverse transcriptase of bis(heteroaryl)piperazine-resistant human immunodeficiency virus type 1 that confers increased sensitivity to other nonnucleoside inhibitors.

@article{Dueweke1993AMI,
  title={A mutation in reverse transcriptase of bis(heteroaryl)piperazine-resistant human immunodeficiency virus type 1 that confers increased sensitivity to other nonnucleoside inhibitors.},
  author={T J Dueweke and T Pushkarskaya and Susan M Poppe and Steven M Swaney and Jia Qi Zhao and Irvin S. Y. Chen and Mario Stevenson and W. Gary Tarpley},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1993},
  volume={90 10},
  pages={4713-7}
}
Several nonnucleoside inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) have been described, including Nevirapine, thiobenzimidazolone (TIBO) derivatives, pyridinone derivatives such as L-697,661, and the bis(heteroaryl)piperazines (BHAPs). HIV-1 resistant to L-697,661 or Nevirapine emerges rapidly in infected patients treated with these drugs, and the resistance is caused primarily by substitutions at amino acids 181 and 103 of RT that also confer cross… CONTINUE READING

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