A mutation in a mitochondrial dehydrogenase/reductase gene causes an increased sensitivity to oxidative stress and mitochondrial defects in the nematode Caenorhabditis elegans.

@article{Fujii2011AMI,
  title={A mutation in a mitochondrial dehydrogenase/reductase gene causes an increased sensitivity to oxidative stress and mitochondrial defects in the nematode Caenorhabditis elegans.},
  author={Michihiko Fujii and Kayo Yasuda and Phil S. Hartman and Dai Ayusawa and Naoaki Ishii},
  journal={Genes to cells : devoted to molecular & cellular mechanisms},
  year={2011},
  volume={16 10},
  pages={1022-34}
}
rad-8 is an interesting mutant that shows increased sensitivities to UV radiation and reactive oxygen species in the nematode Caenorhabditis elegans. In this study, we have characterized rad-8 and have found that rad-8 showed several phenotypes of mitochondrial dysfunction such as a decreased activity of the respiratory chain, increased generation of superoxide anions, increased oxidative damage, increased apoptosis, and abnormal mitochondrial structure. Our genetic analysis has also indicated… CONTINUE READING
2 Citations
43 References
Similar Papers

References

Publications referenced by this paper.
Showing 1-10 of 43 references

The genetics of Caenorhabditis elegans

  • S. Brenner
  • 1974
Highly Influential
4 Excerpts

Genes to Cells

  • M Fujii
  • 2011

Similar Papers

Loading similar papers…