A mutation in X-linked inhibitor of apoptosis (G466X) leads to memory inflation of Epstein-Barr virus-specific T cells.

Abstract

Mutations in the X-linked inhibitor of apoptosis (XIAP) gene have been associated with XLP-like disease, including recurrent Epstein-Barr virus (EBV)-related haemophagocytic lymphohystiocytosis (HLH), but the immunopathogenic bases of EBV-related disease in XIAP deficiency is unknown. We present the first analysis of EBV-specific T cell responses in… (More)
DOI: 10.1111/cei.12427

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@article{LpezGranados2014AMI, title={A mutation in X-linked inhibitor of apoptosis (G466X) leads to memory inflation of Epstein-Barr virus-specific T cells.}, author={Eduardo L{\'o}pez-Granados and Michael Stacey and A-K Kienzler and Sophie R. Sierro and C B Willberg and Colleen Fox and Sylvain Rigaud and Hua Long and Andrew D Hislop and A. B. Rickinson and S. Patel and S. Latour and Paul Klenerman and Helen M. Chapel}, journal={Clinical and experimental immunology}, year={2014}, volume={178 3}, pages={470-82} }