A mutation in UL15 of herpes simplex virus 1 that reduces packaging of cleaved genomes.

@article{Yang2011AMI,
  title={A mutation in UL15 of herpes simplex virus 1 that reduces packaging of cleaved genomes.},
  author={Kui Yang and Elizabeth G Wills and Joel D. Baines},
  journal={Journal of virology},
  year={2011},
  volume={85 22},
  pages={11972-80}
}
Herpesvirus genomic DNA is cleaved from concatemers that accumulate in infected cell nuclei. Genomic DNA is inserted into preassembled capsids through a unique portal vertex. Extensive analyses of viral mutants have indicated that intact capsids, the portal vertex, and all components of a tripartite terminase enzyme are required to both cleave and package viral DNA, suggesting that DNA cleavage and packaging are inextricably linked. Because the processes have not been functionally separable, it… CONTINUE READING