A mutation creating a potential illegitimate microRNA target site in the myostatin gene affects muscularity in sheep

@article{Clop2006AMC,
  title={A mutation creating a potential illegitimate microRNA target site in the myostatin gene affects muscularity in sheep},
  author={Alex Clop and Fabienne Marcq and Haruko Takeda and Dimitri Pirottin and Xavier Tordoir and Bernard Bib{\'e} and Jacques Bouix and Florian Caiment and Jean-Michel Elsen and Francis Eychenne and Catherine Larzul and {\'E}lisabeth Laville and Françoise Meish and Dragan Milenkovic and J Tobin and Carole Charlier and Michel Georges},
  journal={Nature Genetics},
  year={2006},
  volume={38},
  pages={813-818}
}
Texel sheep are renowned for their exceptional meatiness. To identify the genes underlying this economically important feature, we performed a whole-genome scan in a Romanov × Texel F2 population. We mapped a quantitative trait locus with a major effect on muscle mass to chromosome 2 and subsequently fine-mapped it to a chromosome interval encompassing the myostatin (GDF8) gene. We herein demonstrate that the GDF8 allele of Texel sheep is characterized by a G to A transition in the 3′ UTR that… Expand
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