A mutation and expression analysis of the oncogene BRAF in pituitary adenomas.

@article{Ewing2007AMA,
  title={A mutation and expression analysis of the oncogene BRAF in pituitary adenomas.},
  author={Iain Edward Ewing and Stephen Pedder-Smith and Giulia Franchi and Massimiliano Ruscica and Michelle N Emery and Vladimir V Vax and Edwin Fabi{\'a}n Garc{\'i}a and S{\'a}ndor Czirj{\'a}k and Zolt{\'a}n Hanz{\'e}ly and Blerina P Kola and M{\'a}rta Korbonits and Ashley B. Grossman},
  journal={Clinical endocrinology},
  year={2007},
  volume={66 3},
  pages={348-52}
}
OBJECTIVE BRAF is an oncogene that is commonly mutated in both melanomas and papillary thyroid carcinomas, usually at position V600E that leads to constitutive activity in the Ras-mitogen-activated protein kinase (MAPK) pathway. We speculated that this same gene may be either mutated at this site, or overexpressed, in pituitary adenomas. DESIGN AND MEASUREMENTS We sequenced 37 pituitary adenomas for a mutation at the V600E position. In addition, we investigated B-Raf mRNA expression in normal… CONTINUE READING