A mutation affecting amdS expression in Aspergillus nidulans contains a triplication of a cis-acting regulatory sequence

@article{Katz1990AMA,
  title={A mutation affecting amdS expression in Aspergillus nidulans contains a triplication of a cis-acting regulatory sequence},
  author={Margaret E. Katz and Jennifer A. Saleeba and Sandra I. Sapats and Michael J. Hynes},
  journal={Molecular and General Genetics MGG},
  year={1990},
  volume={220},
  pages={373-376}
}
In Aspergillus nidulans expression of the acetamidase structural gene, amdS, is under the control of at least four regulatory genes including the trans-acting amdA regulatory gene. A cis-acting mutation (amdI66) consisting of an 18 by duplication in the 5′ region of the amdS gene results in very high levels of acetamidase activity but only in strains carrying semi-dominant mutations in the amdA gene. In selecting for increased amdS expression in an amdI66 amdA – strain, an A. nidulans strain… CONTINUE READING
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