A mutated retinoic acid receptor-alpha exhibiting dominant-negative activity alters the lineage development of a multipotent hematopoietic cell line.

@article{Tsai1992AMR,
  title={A mutated retinoic acid receptor-alpha exhibiting dominant-negative activity alters the lineage development of a multipotent hematopoietic cell line.},
  author={Sophia Y. Tsai and S Bartelmez and Richard B. Heyman and K. L. Von Damm and Robert Evans and Steven John Collins},
  journal={Genes & development},
  year={1992},
  volume={6 12A},
  pages={
          2258-69
        }
}
The retinoic acid receptor (RAR alpha) is expressed in virtually all hematopoietic lineages, but the role of this transcription factor in regulating the growth and differentiation of hematopoietic progenitors is unknown. We have constructed a mutant RAR alpha that both exhibits dominant-negative activity against the normal RAR alpha in transient expression assays in mouse fibroblasts and inhibits retinoic acid-induced neutrophilic differentiation of the HL-60 human promyelocytic leukemia cell… CONTINUE READING
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