A mutant of melanoma growth stimulating activity does not activate neutrophils but blocks erythrocyte invasion by malaria.

@article{Hesselgesser1995AMO,
  title={A mutant of melanoma growth stimulating activity does not activate neutrophils but blocks erythrocyte invasion by malaria.},
  author={Joseph Hesselgesser and Chetan E. Chitnis and Louis H. Miller and Daniel G. Yansura and Laura C. Simmons and Wayne J. Fairbrother and Claire E. Kotts and Cynthia M. Wirth and B L Gillece-Castro and Richard Horuk},
  journal={The Journal of biological chemistry},
  year={1995},
  volume={270 19},
  pages={11472-6}
}
Alanine scanning mutagenesis of the charged amino acids of melanoma growth stimulating activity (MGSA) was used to identify specific residues that are involved in binding to the human erythrocyte Duffy antigen/chemokine receptor (DARC) and to the type B interleukin-8 receptor (IL-8RB) on neutrophils. Receptor binding and biological studies with the alanine scan mutants of MGSA demonstrate that MGSA binds to DARC and the IL-8RB through distinct binding regions. One of the MGSA mutants, E6A… CONTINUE READING

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