A mutant insulin receptor induces formation of a Shc-growth factor receptor bound protein 2 (Grb2) complex and p21ras-GTP without detectable interaction of insulin receptor substrate 1 (IRS1) with Grb2. Evidence for IRS1-independent p21ras-GTP formation.

@article{Ouwens1994AMI,
  title={A mutant insulin receptor induces formation of a Shc-growth factor receptor bound protein 2 (Grb2) complex and p21ras-GTP without detectable interaction of insulin receptor substrate 1 (IRS1) with Grb2. Evidence for IRS1-independent p21ras-GTP formation.},
  author={D Margriet Ouwens and Gerard C M van der Zon and G. J. Pronk and Johannes L Bos and W. J. M{\"o}ller and Bentley Cheatham and C. Ronald Kahn and Johannes A Maassen},
  journal={The Journal of biological chemistry},
  year={1994},
  volume={269 52},
  pages={
          33116-22
        }
}
The activation of p21ras by receptor tyrosine kinases involves the translocation of the growth factor receptor bound protein 2-mammalian son of sevenless protein (Grb2-SOS) complex to the plasma membrane where p21ras is localized. Insulin receptors induce p21ras-GTP formation by two possible mechanisms: tyrosine phosphorylation of insulin receptor substrate 1 (IRS1) and its subsequent association with Grb2, or Shc phosphorylation and its subsequent association with Grb2. We investigated the… CONTINUE READING

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