A mutant form of the tax protein of bovine leukemia virus (BLV), with enhanced transactivation activity, increases expression and propagation of BLV in vitro but not in vivo.

@article{Tajima2003AMF,
  title={A mutant form of the tax protein of bovine leukemia virus (BLV), with enhanced transactivation activity, increases expression and propagation of BLV in vitro but not in vivo.},
  author={Shigeru Tajima and Masahiko Takahashi and Shin-nosuke Takeshima and Satoru Konnai and Shan Ai Yin and Shinobu Watarai and Yoshimasa Tanaka and Misao Onuma and Kosuke Okada and Yoko Aida},
  journal={Journal of virology},
  year={2003},
  volume={77 3},
  pages={1894-903}
}
In a previous study, we identified an interesting mutant form of the Tax protein of bovine leukemia virus (BLV), designated D247G. This mutant protein strongly transactivated the long terminal repeat of BLV and was also able to transactivate the cellular proto-oncogene c-fos. This finding suggested that BLV that encode the mutant protein might propagate and induce lymphoma more efficiently than wild-type BLV. To characterize the effects of the strong transactivation activity of the mutant Tax… CONTINUE READING