A mutant alpha subunit of Gi2 induces neoplastic transformation of Rat-1 cells.

@article{Pace1991AMA,
  title={A mutant alpha subunit of Gi2 induces neoplastic transformation of Rat-1 cells.},
  author={Ann M. Pace and Yung Wong and Henry R. Bourne},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1991},
  volume={88 16},
  pages={7031-5}
}
In a recently discovered class of oncogenes, GTPase-inhibiting mutations constitutively activate alpha subunits of signal-transducing guanine nucleotide-binding proteins (G proteins). Somatic mutations in a subclass of endocrine tumors are found in the arginine-179 codon of the alpha subunit of Gi2 (alpha i2), creating the putative gip2 oncogene. We have tested the ability of gip2 to mediate neoplastic transformation of Rat-1 and NIH 3T3 fibroblasts in tissue culture. Expression of a mutant… CONTINUE READING
23 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 23 extracted citations

Similar Papers

Loading similar papers…