A mutagenesis-derived Lrp5 mouse mutant with abnormal retinal vasculature and low bone mineral density

@inproceedings{Charette2017AML,
  title={A mutagenesis-derived Lrp5 mouse mutant with abnormal retinal vasculature and low bone mineral density},
  author={Jeremy R. Charette and Sarah E. Earp and Brent A. Bell and Cheryl L. Ackert-Bicknell and Dana A. Godfrey and Sujata Rao and Bela Anand-Apte and Patsy M. Nishina and Neal S Peachey},
  booktitle={Molecular vision},
  year={2017}
}
PURPOSE Familial exudative vitreoretinopathy (FEVR) is caused by mutations in the genes encoding low-density lipoprotein receptor-related protein (LRP5) or its interacting partners, namely frizzled class receptor 4 (FZD4) and norrin cystine knot growth factor (NDP). Mouse models for Lrp5, Fzd4, and Ndp have proven to be important for understanding the… CONTINUE READING