A muscle-type tropomyosin in human fibroblasts: evidence for expression by an alternative RNA splicing mechanism.

@article{Macleod1985AMT,
  title={A muscle-type tropomyosin in human fibroblasts: evidence for expression by an alternative RNA splicing mechanism.},
  author={A Robert Macleod and C H Houlker and Fernando Castro Reinach and Lawrence B. Smillie and Kevin Talbot and Girish Modi and Frank S. Walsh},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1985},
  volume={82 23},
  pages={7835-9}
}
We have isolated a cDNA clone from a human fibroblast cDNA library that contains the entire protein-coding region of a 1.1-kilobase mRNA. This mRNA encodes a 284-amino acid tropomyosin, the primary structure of which most closely resembles smooth muscle tropomyosin. Thus, the expression of both 284-amino acid muscle-type and 247-amino acid non-muscle-type tropomyosins appears to be a normal feature of human non-muscle cells. We also present evidence to suggest that this cytoskeletal tropomyosin… CONTINUE READING

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