A muscarinic agonist inhibits reflex bronchoconstriction in normal but not in asthmatic subjects.

@article{Minette1989AMA,
  title={A muscarinic agonist inhibits reflex bronchoconstriction in normal but not in asthmatic subjects.},
  author={P A Minette and Jan-Willem J Lammers and C. M. S. Dixon and M T McCusker and Peter J Barnes},
  journal={Journal of applied physiology},
  year={1989},
  volume={67 6},
  pages={2461-5}
}
Muscarinic receptors of the M2 subtype, which inhibit acetylcholine release from cholinergic nerves (autoreceptors), have been described in animal and human bronchi in vitro. We investigated whether these receptors may be involved in feedback inhibition of cholinergic reflex bronchoconstriction induced by sulfur dioxide (SO2) in seven nonasthmatic atopic subjects and in six mild asthmatic subjects. In a control experiment, total respiratory resistance (Rrs) was increased by 30 +/- 5% in… CONTINUE READING