A murine tumor producing a matrix of basement membrane

  title={A murine tumor producing a matrix of basement membrane},
  author={Roslyn W. Orkin and P Gehron and E B McGoodwin and George Robert Martin and T V Valentine and R L Swarm},
  journal={The Journal of Experimental Medicine},
  pages={204 - 220}
We have studied a murine tumor previously classified as a poorly differentiated chondrosarcoma. Although the cells in this tumor are surrounded by large quantities of extracellular matrix material, the matrix fails to react with stains specific for the sulfated glycosaminoglycans present in normal cartilage. Here we show at the ultrastructural level that the tumor matrix is a homogeneous, nonfibrillar material, resembling basement membrane. Neither the proteoglycan matrix granules nor collagen… CONTINUE READING


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Biochemistry of basement membranes

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