A murine model of opioid-induced hyperalgesia.

  title={A murine model of opioid-induced hyperalgesia.},
  author={Xiangqi Li and Martin S. Angst and John David Clark},
  journal={Brain research. Molecular brain research},
  volume={86 1-2},
Controversies surround the possible long-term physiological and psychological consequences of opioid use. Analgesic tolerance and addiction are commonly at the center of these controversies, but other concerns exist as well. A growing body of evidence suggests that hyperalgesia caused by the chronic administration of opioids can occur in laboratory animals and in humans. In these studies we describe a murine model of opioid-induced hyperalgesia (OIH). After the treatment of mice for 6 days with… CONTINUE READING


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