A murine model of antibody-mediated hyperacute rejection by galactose-alpha(1,3)galactose antibodies in Gal o/o mice.

@article{Mckenzie1998AMM,
  title={A murine model of antibody-mediated hyperacute rejection by galactose-alpha(1,3)galactose antibodies in Gal o/o mice.},
  author={Ian F.C. Mckenzie and Yu Qin Li and Kathryn Patton and Aron D. Thall and Mauro Sergio Sandrin},
  journal={Transplantation},
  year={1998},
  volume={66 6},
  pages={754-63}
}
BACKGROUND In pig-to-primate/human xenografts, hyperacute rejection of primarily vascularized organs usually occurs in 10-60 min and is due to the reaction of the recipients' natural antibodies with antigens expressed on the donor endothelium, the fixation of complement, and ultimately vascular stasis and hemorrhage. Surprisingly, the major target of the natural antibodies is the disaccharide galactose-alpha(1,3)galactose (Gal alpha(1,3)Gal), which is found on many different molecules in pig… CONTINUE READING

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