A murine model for assessing the respiratory hypersensitivity potential of chemical allergens.

@article{Satoh1995AMM,
  title={A murine model for assessing the respiratory hypersensitivity potential of chemical allergens.},
  author={Takahiro Satoh and J A Kramarik and David J. Tollerud and Meryl H. Karol},
  journal={Toxicology letters},
  year={1995},
  volume={78 1},
  pages={57-66}
}
Using equimolar quantities of 2 chemical allergens, toluene diisocyanate (TDI), noted for its ability to cause respiratory hypersensitivity, and dinitrochlorobenzene (DNCB), noted for its dermal sensitizing activity, the mouse was evaluated as a possible model to indicate respiratory hypersensitivity. A previously published procedure (Garssen et al. (1989) Immunology 68, 51-58) was followed whereby chemicals were applied epicutaneously to the shaved flank of BALB/c mice. Eight days later… CONTINUE READING