A murine AP-endonuclease gene-targeted deficiency with post-implantation embryonic progression and ionizing radiation sensitivity.

@article{Ludwig1998AMA,
  title={A murine AP-endonuclease gene-targeted deficiency with post-implantation embryonic progression and ionizing radiation sensitivity.},
  author={Dale L. Ludwig and Mark A Macinnes and Yuichi Takiguchi and P E Purtymun and Melinda S Henrie and Margaret Flannery and Juanito Meneses and Roger A. Pedersen and David J. Chen},
  journal={Mutation research},
  year={1998},
  volume={409 1},
  pages={17-29}
}
Apurinic/apyrimidinic endonuclease (here designated APE/REF) carries out repair incision at abasic or single-strand break damages in mammals. This multifunctional protein also has putative role(s) as a cysteine 'reducing factor' (REF) in cell-stress transcriptional responses. To assess the significance of APE/REF for embryonic teratogenesis we constructed a more precisely targeted Ape/Ref-deficient genotype in mice. Ape/Ref gene replacement in ES cells eliminated the potential of APE/REF… CONTINUE READING