A multivariate prediction model for microarray cross-hybridization

  title={A multivariate prediction model for microarray cross-hybridization},
  author={Yian A. Chen and Cheng-Chung Chou and Xinghua Lu and Elizabeth H. Slate and Konan Peck and Wenying Xu and Eberhard O. Voit and Jonas S. Almeida},
  journal={BMC Bioinformatics},
  pages={101 - 101}
Expression microarray analysis is one of the most popular molecular diagnostic techniques in the post-genomic era. However, this technique faces the fundamental problem of potential cross-hybridization. This is a pervasive problem for both oligonucleotide and cDNA microarrays; it is considered particularly problematic for the latter. No comprehensive multivariate predictive modeling has been performed to understand how multiple variables contribute to (cross-) hybridization. We propose a… CONTINUE READING