A multivariate approach to investigate the combined biological effects of multiple exposures

@article{Jain2018AMA,
  title={A multivariate approach to investigate the combined biological effects of multiple exposures},
  author={Pooja Jain and Paolo Vineis and Benoit Liquet and Jelle J Vlaanderen and Barbara Bodinier and Karin van Veldhoven and Manolis Kogevinas and Toby J. Athersuch and Laia Font-Ribera and Cristina M. Villanueva and Roel C.H. Vermeulen and Marc Chadeau-Hyam},
  journal={Journal of Epidemiology and Community Health},
  year={2018},
  volume={72},
  pages={564 - 571}
}
Epidemiological studies provide evidence that environmental exposures may affect health through complex mixtures. Formal investigation of the effect of exposure mixtures is usually achieved by modelling interactions, which relies on strong assumptions relating to the identity and the number of the exposures involved in such interactions, and on the order and parametric form of these interactions. These hypotheses become difficult to formulate and justify in an exposome context, where… 
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