A multivariate analysis of 416 patients with glioblastoma multiforme: prognosis, extent of resection, and survival.

@article{Lacroix2001AMA,
  title={A multivariate analysis of 416 patients with glioblastoma multiforme: prognosis, extent of resection, and survival.},
  author={M Lacroix and Dima Abi‐Said and Daryl R. Fourney and Ziya L. Gokaslan and Wenxin Shi and Franco DeMonte and Frederick F. Lang and Ian E. McCutcheon and Samuel J. Hassenbusch and Eric C. Holland and Kenneth R. Hess and C Michael and D J Miller and Raymond E. Sawaya},
  journal={Journal of neurosurgery},
  year={2001},
  volume={95 2},
  pages={
          190-8
        }
}
OBJECT The extent of tumor resection that should be undertaken in patients with glioblastoma multiforme (GBM) remains controversial. The purpose of this study was to identify significant independent predictors of survival in these patients and to determine whether the extent of resection was associated with increased survival time. METHODS The authors retrospectively analyzed 416 consecutive patients with histologically proven GBM who underwent tumor resection at the authors' institution… 
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Does Extent of Resection Increase the Survival in Patients with Glioblastoma Multiformis ?

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CE-RTV and EOR were found to be significant predictors of survival after GBM resection, and CERTV was the more significant predictor of survival compared with EOR, suggesting that the volume of residual contrast-enhancing tumor may be a more accurate and meaningful reflection of the pathobiology of GBM.

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The present study shows that patients with recurrent glioblastoma can have improved survival with repeated resections, and the findings of this study may be limited by an intrinsic bias associated with patient selection.

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