A multiscale model for eccentric and concentric cardiac growth through sarcomerogenesis.

@article{Gktepe2010AMM,
  title={A multiscale model for eccentric and concentric cardiac growth through sarcomerogenesis.},
  author={Serdar G{\"o}ktepe and Oscar J. Abilez and Kevin Kit Parker and Ellen Kuhl},
  journal={Journal of theoretical biology},
  year={2010},
  volume={265 3},
  pages={433-42}
}
We present a novel computational model for maladaptive cardiac growth in which kinematic changes of the cardiac chambers are attributed to alterations in cytoskeletal architecture and in cellular morphology. We adopt the concept of finite volume growth characterized through the multiplicative decomposition of the deformation gradient into an elastic part… CONTINUE READING