A multiscale mathematical model for oncolytic virotherapy.

  title={A multiscale mathematical model for oncolytic virotherapy.},
  author={Leticia Ribeiro Paiva and Christopher J Binny and Silvio C. Ferreira and Marcelo Lobato Martins},
  journal={Cancer research},
  volume={69 3},
One of the most promising strategies to treat cancer is attacking it with viruses. Oncolytic viruses can kill tumor cells specifically or induce anticancer immune response. A multiscale model for virotherapy of cancer is investigated through simulations. It was found that, for intratumoral virus administration, a solid tumor can be completely eradicated or keep growing after a transient remission. Furthermore, the model reveals undamped oscillatory dynamics of tumor cells and virus populations… CONTINUE READING