A multinational, randomized, placebo-controlled trial to assess the immunogenicity, safety, and tolerability of live attenuated influenza vaccine coadministered with oral poliovirus vaccine in healthy young children.

@article{Breiman2009AMR,
  title={A multinational, randomized, placebo-controlled trial to assess the immunogenicity, safety, and tolerability of live attenuated influenza vaccine coadministered with oral poliovirus vaccine in healthy young children.},
  author={Robert F. Breiman and William L A Brooks and Doli Rani Goswami and Rosanna M Lagos and Charissa Fay Corazon Borja-Tabora and Claudio Franco Lanata and Jaime A Londo{\~n}o and Lucy Chai See Lum and Ruth Rappaport and Ahmad Razmpour and Robert E. Walker and William C. Gruber and Bruce D Forrest},
  journal={Vaccine},
  year={2009},
  volume={27 40},
  pages={5472-9}
}
Live attenuated influenza vaccine (LAIV) provides a useful tool to rapidly immunize populations in the developing world to prevent influenza outbreaks. In this noninferiority trial conducted in Asia and South America, where oral poliovirus vaccine (OPV) is still used, 2503 children aged 6 to <36 months with three polio immunizations were randomized to receive LAIV+OPV, placebo+OPV, or LAIV only. Immune responses in children receiving concomitant LAIV+OPV were noninferior to those observed in… CONTINUE READING

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