A multimodal intervention for patients with secondary progressive multiple sclerosis: feasibility and effect on fatigue.

@article{Bisht2014AMI,
  title={A multimodal intervention for patients with secondary progressive multiple sclerosis: feasibility and effect on fatigue.},
  author={Babita Bisht and Warren G. Darling and Ruth E. Grossmann and E. Torage Shivapour and Susan K. Lutgendorf and Linda G. Snetselaar and Michael J. Hall and M. Bridget Zimmerman and Terry L Wahls},
  journal={Journal of alternative and complementary medicine},
  year={2014},
  volume={20 5},
  pages={
          347-55
        }
}
BACKGROUND Multiple sclerosis is an autoimmune disease influenced by environmental factors. OBJECTIVES The feasibility of a multimodal intervention and its effect on perceived fatigue in patients with secondary progressive multiple sclerosis were assessed. DESIGN/SETTING This was a single-arm, open-label intervention study in an outpatient setting. INTERVENTIONS A multimodal intervention including a modified paleolithic diet with supplements, stretching, strengthening exercises with… Expand

Paper Mentions

Interventional Clinical Trial
A key question in efforts to reduce symptoms and improve quality of life for multiple sclerosis (MS) patients is whether a therapeutic lifestyle (diet, stress reduction and… Expand
ConditionsClinically Isolated Syndrome, Relapsing Remitting Multiple Sclerosis
InterventionBehavioral
Interventional Clinical Trial
The overarching goal of this project is to critically evaluate the efficacy of incorporating dietary guidance within multiple sclerosis (MS) care for improving long-term quality of life… Expand
ConditionsMultiple Sclerosis, Relapsing-Remitting
InterventionBehavioral, Dietary Supplement
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The purpose of this study is to compare the effect of the Swank Diet (low saturated fat) and the Wahls Elimination Diet (modified paleo) on fatigue levels in individuals with… Expand
ConditionsMultiple Sclerosis, Multiple Sclerosis, Relapsing-Remitting
InterventionBehavioral
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ConditionsClinically Isolated Syndrome, Multiple Sclerosis
InterventionBehavioral
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References

SHOWING 1-10 OF 36 REFERENCES
A randomized pilot study of naturopathic medicine in multiple sclerosis.
TLDR
Evaluated naturopathic medicine combined with usual care for MS showed a trend in improvement in the General Health subscale of the SF-36, Timed Walk, and neurologic impairment, which warrants further investigation. Expand
The effect of exercise therapy on fatigue in multiple sclerosis
TLDR
Exercise therapy has the potential to induce a positive effect on MS fatigue, but findings are heterogeneous probably because many studies have applied non-fatigued study populations, emphasizing the need for future studies within this field. Expand
Long–term exercise improves functional impairment but not quality of life in multiple sclerosis
TLDR
MSFC is more sensitive than EDSS in the detection of improvement in functional impairment as a result of regular exercise, and the unfavourable results from HRQOL do not rule out the possibility that other types of exercise programs may improve it in MS. Expand
Comparison of the effects of acetyl l-carnitine and amantadine for the treatment of fatigue in multiple sclerosis: results of a pilot, randomised, double-blind, crossover trial
TLDR
The results of this study show that ALCAR is better tolerated and more effective than amantadine for the treatment of MS-related fatigue. Expand
Health-related quality of life in secondary progressive multiple sclerosis
TLDR
Health-related quality of life (HRQoL) measures the broader impact of MS and might indicate less obvious disease burdens and physical disability (EDSS and Arm Index), disease progression and fatigue strongly influenced this. Expand
Treatment of fatigue in multiple sclerosis: a systematic review of the literature.
TLDR
Effectiveness of both pharmacological and psychosocial/psychological interventions for fatigue in MS was modest at best and often absent, and there is little evidence-based advice that can be offered to people with MS to help manage their fatigue. Expand
Neuromuscular electrical stimulation and dietary interventions to reduce oxidative stress in a secondary progressive multiple sclerosis patient leads to marked gains in function: a case report
TLDR
After 8 months of neuromuscular electrical stimulation the patient's function had improved sufficiently that she no longer used a scooter or cane and rode her bicycle routinely 8 miles, including hills. Expand
Rehabilitation with neuromuscular electrical stimulation leads to functional gains in ambulation in patients with secondary progressive and primary progressive multiple sclerosis: a case series report.
TLDR
NMES, an approved Food and Drug Administration treatment modality for muscle spasm, muscle pain, and disuse atrophy-all of which are commonly present in patients with gait disability associated with SPMS and PPMS-was associated with measurable gains in ambulatory function. Expand
Health-related quality of life outcomes at 1 and 5 years after a residential retreat promoting lifestyle modification for people with multiple sclerosis
TLDR
Attendance at a retreat promoting lifestyle modification for the integrated management of MS appears to have positive effects on short and medium-term health-related quality of life (HRQOL). Expand
Interferon β for secondary progressive multiple sclerosis: a systematic review
TLDR
3 year treatment with IFN β does not delay permanent disability in SPMS but reduces relapse risk, indicating that the anti-inflammatory effect of IFNβ is unable to prevent MS progression once it has become established. Expand
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