A multilocus likelihood approach to joint modeling of linkage, parental diplotype and gene order in a full-sib family

@article{Lu2004AML,
  title={A multilocus likelihood approach to joint modeling of linkage, parental diplotype and gene order in a full-sib family},
  author={Qing Lu and Yuehua Cui and Rongling Wu},
  journal={BMC Genetics},
  year={2004},
  volume={5},
  pages={20 - 20}
}
Unlike a pedigree initiated with two inbred lines, a full-sib family derived from two outbred parents frequently has many different segregation types of markers whose linkage phases are not known prior to linkage analysis. We formulate a general model of simultaneously estimating linkage, parental diplotype and gene order through multi-point analysis in a full-sib family. Our model is based on a multinomial mixture model taking into account different diplotypes and gene orders, weighted by… CONTINUE READING
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